The transcription factor HNF3β is required in visceral endoderm for normal primitive streak morphogenesis
نویسندگان
چکیده
Daniel Dufort1, Lois Schwartz1, Kendraprasad Harpal1 and Janet Rossant1,2,3,* 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada, M5G 1X5 2Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada, M5S 1A8 3Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada, M5S 1A8 *Author for correspondence (e-mail: [email protected])
منابع مشابه
The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis.
During early embryogenesis, the transcription factor HNF3beta is expressed in visceral and definitive endoderm, node, notochord and floorplate. A targeted mutation in the HNF3&bgr ; gene results in the lack of a definitive node and notochord. Furthermore, lack of HNF3beta results in failure of proper primitive streak elongation. To address whether HNF3beta is required in visceral endoderm, we h...
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